Start Elucidating pathway arsenic methylation

Elucidating pathway arsenic methylation

Bahman Asgharian, Applied Research Associates, Raleigh, NC.

The three major challenges in the study of acquired and innate diseases, as well as drugs and toxicants that affect the retina in man and experimental animals, are: difficulty in early noninvasive detection of decreased visual function and/or loss with conventional tools and techniques; determination of the cellular site(s) and mechanism(s) of action; and monitoring of progression and/or repair following different treatment/therapeutic regimens.

Advances in ocular imaging techniques, for man and experimental animals, provide the ability to noninvasively image individual retinal cells, the optic nerve, and retinal vasculature in living eyes.

Susan Tilton, Oregon State University, Corvallis, OR.

Use of Non-Apical Assay Data in an Integrated Approach to Testing and Assessment of Chemical Mixtures in the Environment: The Advent of Adverse Outcome Pathway Footprinting. Eukaryotic cells contain extracellular organelles named microvesicles (e.g., exosomes, nanovesicles) that are released into the microenvironment.

This will be followed by a panel discussion of the merits of these alternative approaches and what steps are needed to move toward validation.

Testing of Polycyclic Aromatic Hydrocarbons at the National Toxicology Program. The Genetic Toxicity of Complex Mixtures of Polycyclic Aromatic Hydrocarbons: Evaluating the Dose-Additivity Assumption Using a Transgenic Mouse Model. Mechanism-Based Classification of PAH Mixtures to Predict Carcinogenic Potential.

The presentations will cover the study of different cell populations within the retina and of the supporting vascular networks.

Each presentation will share the fundamental aspects of the retina and imaging modalities employed in their work.

The session will be of interest to basic scientists, clinicians, and researchers engaged in drug development and testing. Jacque Duncan, University of California San Francisco, San Francisco, CA.

Mitochondria-Mediated Retinotoxicity: Determining Pathophysiological Mechanisms Using Multifaceted Image Analysis and Biochemical Techniques.

Günter Oberdörster, University of Rochester, Rochester, NY.